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Characterization of nanoplatforms. (A) Particle size distribution and Transmission electron <t>microscope</t> (TEM) image of PSSQ micelles. (B) Critical micellar concentration (CMC) of PSSQ micelles. (C-E) Changes of particle size and TEM image of PSSQ micelles in different media. Particle size and TEM image of (F) TLP and (G) PSSQ@TLP. (H) Cumulative release profiles of SN38 from PSSQ@TLP in different release media ( n = 3). (I) Storage stability of PSSQ@TLP in phosphate-buffered saline (PBS) (pH 7.4) at 37 °C (evaluated by particle size and PDI changes, data are shown as mean ± SD, n = 3).
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Characterization of nanoplatforms. (A) Particle size distribution and Transmission electron <t>microscope</t> (TEM) image of PSSQ micelles. (B) Critical micellar concentration (CMC) of PSSQ micelles. (C-E) Changes of particle size and TEM image of PSSQ micelles in different media. Particle size and TEM image of (F) TLP and (G) PSSQ@TLP. (H) Cumulative release profiles of SN38 from PSSQ@TLP in different release media ( n = 3). (I) Storage stability of PSSQ@TLP in phosphate-buffered saline (PBS) (pH 7.4) at 37 °C (evaluated by particle size and PDI changes, data are shown as mean ± SD, n = 3).
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Characterization of nanoplatforms. (A) Particle size distribution and Transmission electron <t>microscope</t> (TEM) image of PSSQ micelles. (B) Critical micellar concentration (CMC) of PSSQ micelles. (C-E) Changes of particle size and TEM image of PSSQ micelles in different media. Particle size and TEM image of (F) TLP and (G) PSSQ@TLP. (H) Cumulative release profiles of SN38 from PSSQ@TLP in different release media ( n = 3). (I) Storage stability of PSSQ@TLP in phosphate-buffered saline (PBS) (pH 7.4) at 37 °C (evaluated by particle size and PDI changes, data are shown as mean ± SD, n = 3).
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Characterization of nanoplatforms. (A) Particle size distribution and Transmission electron microscope (TEM) image of PSSQ micelles. (B) Critical micellar concentration (CMC) of PSSQ micelles. (C-E) Changes of particle size and TEM image of PSSQ micelles in different media. Particle size and TEM image of (F) TLP and (G) PSSQ@TLP. (H) Cumulative release profiles of SN38 from PSSQ@TLP in different release media ( n = 3). (I) Storage stability of PSSQ@TLP in phosphate-buffered saline (PBS) (pH 7.4) at 37 °C (evaluated by particle size and PDI changes, data are shown as mean ± SD, n = 3).

Journal: International Journal of Pharmaceutics: X

Article Title: Encapsulating GSH/NQO1-responsive SN38 prodrug micelles with Timosaponin AIII-based multifunctional liposomes for tumor-targeted chemotherapy

doi: 10.1016/j.ijpx.2026.100497

Figure Lengend Snippet: Characterization of nanoplatforms. (A) Particle size distribution and Transmission electron microscope (TEM) image of PSSQ micelles. (B) Critical micellar concentration (CMC) of PSSQ micelles. (C-E) Changes of particle size and TEM image of PSSQ micelles in different media. Particle size and TEM image of (F) TLP and (G) PSSQ@TLP. (H) Cumulative release profiles of SN38 from PSSQ@TLP in different release media ( n = 3). (I) Storage stability of PSSQ@TLP in phosphate-buffered saline (PBS) (pH 7.4) at 37 °C (evaluated by particle size and PDI changes, data are shown as mean ± SD, n = 3).

Article Snippet: Cells were washed with saline, fixed with 4% paraformaldehyde, stained with DAPI, and imaged using a confocal laser scanning microscope (CLSM, STELLARIS 5, Leica, Germany).

Techniques: Transmission Assay, Microscopy, Concentration Assay, Saline